The Xavier Musketeers (10-10) will try to get back above the .500 mark when they host the St. John’s Red Storm (13-7) on Wednesday night. Xavier is coming off back-to-back road losses against top-25 teams, including a 99-56 blowout at No. 1 UConn on Sunday. St. John’s snapped a three-game losing streak with a 70-50 win over Villanova last Wednesday, and it has been off since then. The Red Storm cruised to an 81-66 victory when these teams met on Dec. 20. 

Tipoff is set for 6:30 p.m. ET on Wednesday at the Cintas Center. Xavier is favored by 1.5 points in the latest Xavier vs. St. John’s odds, while the over/under is 157 points, per SportsLine consensus. Before entering any St. John’s vs. Xavier picks, you’ll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 13 of the 2023-24 season on a 120-78 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 20-7 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has set its sights on St. John’s-Xavier. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

• Xavier vs. St. John’s spread: Xavier -1.5
• Xavier vs. St. John’s over/under: 157 points
• Xavier vs. St. John’s money line: Xavier -125, St. John’s +105
• Xavier vs. St. John’s picks: See picks here

Why Xavier can cover

Xavier will be happy to return home for this game, as it has been excellent in front of its home fans this season. The Musketeers have won five of their last six home games, with their one loss being an 80-75 setback against then-No. 4 UConn three weeks ago. They picked up wins over Butler and Georgetown in their most recent games at the Cintas Center.

Senior guard Quincy Olivari leads Xavier with 17.8 points and 4.8 rebounds per game, while sophomore guard Desmond Claude is adding 16.0 points, 4.6 rebounds and 3.6 assists. Senior guard Dayvion McKnight is also in double figures with 11.4 points and a team-high 4.8 assists. The Musketeers have won seven of their last eight home games against St. John’s.

Why St. John’s can cover

St. John’s got back on track with a 70-50 win over Villanova last Wednesday, as senior center Joel Soriano had 21 points and nine rebounds. Soriano, who is nearly averaging a double-double with 16.4 points and 9.7 rebounds, shot 8 of 9 from the floor against Villanova. The Red Storm have been sidelined since that win, so they will be well rested coming into this game. 

Xavier is coming off its worst loss in 51 years, getting crushed by No. 1 UConn in a 99-56 final on Sunday. The Musketeers have already lost to the Red Storm once this season, as St. John’s scored 14 points off 18 turnovers in the Big East opener for both teams. St. John’s has covered the spread in 11 of its last 16 games, including seven of its last eight road games. See which team to pick here. 

How to make Xavier vs. St. John’s picks

The model has simulated St. John’s vs. Xavier 10,000 times and the results are in. The model is leaning Under, and it’s also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Xavier vs. St. John’s, and which side of the spread hits well over 50% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 120-78 roll on its top-ranked college basketball picks, and find out.