In a significant advancement for individuals living with food allergies, a new study published in the New England Journal of Medicine reveals that the drug omalizumab, commonly known as Xolair, enables patients to tolerate higher doses of allergenic foods before developing a reaction. This breakthrough not only provides a potential safeguard against accidental exposure to allergens but also leads to milder reactions if exposure occurs.

First FDA-Approved Drug for Multiple Food Allergies

The U.S. Food and Drug Administration (FDA) expanded the approval of Xolair to include treatment of food allergies in anyone one year or older. This makes it the first drug approved to treat allergies to multiple foods. The approval opens new therapeutic avenues for patients allergic to foods such as peanuts, milk, eggs, walnuts, and wheat.

How Does Xolair Work?

Xolair works by mopping up immunoglobulin E (IgE) cells. These cells activate the immune cells responsible for inflammation and allergic reactions. By reducing the number of active IgE cells, Xolair helps to lessen the severity of allergic reactions to specific foods. However, it is vital to note that Xolair is not intended to be used during an allergic reaction, but rather to be taken regularly every few weeks to reduce the risk of reactions over time.

Impressive Results in Clinical Trials

The study included 177 children aged 1 to 17. The results showed that 67% of those who took Xolair were able to tolerate higher doses of peanut without a severe allergic reaction, compared to only 7% of those receiving a placebo. In another trial, 68% of patients allergic to peanuts and at least two other foods were able to consume approximately 2.5 peanuts without symptoms after taking Xolair for 4 to 5 months. These findings signify a significant improvement in quality of life for those living with severe food allergies.

Cost and Coverage of Xolair

While the drug is designed to be a maintenance therapy, it is not without cost. The price of the injections is estimated to be around $2,900 for children and $5,000 for adults each month. The cost can be a substantial financial burden for many families. However, insurers may cover the drug, and a patient assistance program is available for the uninsured.

Side Effects and Safety Considerations

Common side effects of Xolair include fever and a reaction at the injection site. In rare cases, the drug can trigger anaphylaxis, a severe and potentially life-threatening allergic reaction. Therefore, it is essential to discuss potential risks and benefits with a healthcare provider before starting treatment with Xolair.

Despite its cost and potential side effects, Xolair offers a new layer of safety and peace of mind for those living with severe food allergies. It is not a cure, but it is a promising step towards better management of food allergies.