Using a machine-learning framework to study the diffusion of biomedical knowledge in the literature, we find that scientific ideas experience popularity booms and busts when knowledge diffusion is constricted, which leads to adverse consequences for science and scientists. Our work highlights the need for research to have an effect on diverse audiences to achieve sustained scientific advancement.
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References
-
Belikov, A. V., Rzhetsky, A. & Evans, J. Prediction of robust scientific facts from literature. Nat. Mach. Intell. 4, 445–454 (2022). This paper shows that replication rates increase with the social and institutional diversity of research activity.
Google Scholar
-
Xu, J. et al. Building a PubMed knowledge graph. Sci. Data 7, 205 (2020). Our work leverages the dataset described by this paper.
Google Scholar
-
Azoulay, P., Fons-Rosen, C. & Zivin, J. S. G. Does science advance one funeral at a time? Am. Econ. Rev. 109, 2889–2920 (2019). This paper shows how the death of ‘star’ biomedical scientists shapes the intellectual trajectories of subfields in biomedicine.
Google Scholar
-
Le, Q. & Mikolov, T. Distributed representations of sentences and documents. In Proc. of the 31st International Conf. on Machine Learning (eds. Xing, E. P. & Jebara, T.) 1188–1196 (PMLR, 2014). Our work adapts the neural embedding model introduced in this proceeding.
-
Nguyen, C. T. Echo chambers and epistemic bubbles. Episteme 17, 141–161 (2020). This paper presents the conceptual distinction between epistemic bubbles and echo chambers.
Google Scholar
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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Kang, D. et al. Limited diffusion of scientific knowledge forecasts collapse. Nat. Hum. Behav. https://doi.org/10.1038/s41562-024-02041-0 (2024).
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Lack of diffusion of popular scientific ideas marks the presence of epistemic ‘bubbles’.
Nat Hum Behav (2025). https://doi.org/10.1038/s41562-024-02042-z
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Published: 02 January 2025
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DOI: https://doi.org/10.1038/s41562-024-02042-z