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Openness guides discovery

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In reality, research projects grow through an evolutionary process. Variation — the substrate of evolution — is provided through the emergence of new questions and avenues of investigation. The research team must then choose which directions to pursue, a process akin to natural selection1. Along with this evolution at the macro-scale, a much more orderly process is required at the micro-scale. Within each step, thoughtful study design leads to robust experiments and analyses. This complementarity between evolution and design best encapsulates the process of discovery: in ‘night science’ we evolve ideas for the next step, while ‘day science’ tests them2.

A project’s evolutionary history is generally obscured in the resulting scientific publication. The publication’s function is to justify and communicate the project’s main results; it is not a historical account. Instead of recounting all of the project’s dried-up branches, publications zoom in on a single lineage in its evolution: the steps that led to the most interesting result (Fig. 1c). Publications typically describe the discovery as it ideally should have happened, reporting only the evidence relevant to the proposed claims3.

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Fig. 1: Project design and evolution.

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Acknowledgements

We thank Gustavo S. França for assistance with the figure and James C. Kaufmann, Judith Berman, Amir Mitchell and Yoav Gilad for critical comments.

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Authors and Affiliations

  1. Institute for Systems Genetics, NYU Langone Health, New York, NY, USA

    Itai Yanai

  2. Institute for Computer Science & Department of Biology, Heinrich Heine University, Düsseldorf, Germany

    Martin J. Lercher

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  1. Itai Yanai
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  2. Martin J. Lercher
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Itai Yanai.

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Yanai, I., Lercher, M.J. Openness guides discovery.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02635-7

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  • Published: 02 April 2025

  • DOI: https://doi.org/10.1038/s41587-025-02635-7

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