Although single-cell RNA-sequencing has revolutionized biomedical research, exploring cell states from an extracellular vesicle viewpoint has remained elusive. We present an algorithm, SEVtras, that accurately captures signals from small extracellular vesicles and determines source cell-type secretion activity. SEVtras unlocks an extracellular dimension for single-cell analysis with diagnostic potential.
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This is a summary of: He, R., Zhu, J., Ji, P. & Zhao, F. SEVtras delineates small extracellular vesicles at droplet resolution from single-cell transcriptomes. Nat. Methods https://doi.org/10.1038/s41592-023-02117-1 (2023).
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SEVtras characterizes cell-type-specific small extracellular vesicle secretion.
Nat Methods (2023). https://doi.org/10.1038/s41592-023-02118-0
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Published: 04 December 2023
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DOI: https://doi.org/10.1038/s41592-023-02118-0