-
Japanese Scientists Unlock Nature’s Wood-Eating Secrets
Summary: Researchers at Kobe University have developed a novel test substrate that allows the first-ever measurement of the speed and mechanism of a fungal enzyme that breaks down wood, paving the way for improved biofuel and biochemical production. Estimated reading time: 5 minutes In an advance for biofuel and biochemical research, scientists at Kobe University…
-
The UK’s $1-billion bet to create technologies that change the world
After a decade building quantum-computing hardware, Jacques Carolan decided he needed a change. “I wanted to work on technologies that were more directly related to human health,” he says. So in 2021, he pivoted to neuroscience with the aim of building optical technologies to understand the brain. Last year, another opportunity turned Carolan’s head. The…
-
Why AI might be a game-changer for Africa
To an outside observer, Olubayo Adekanmbi’s career in telecommunications epitomized success. At Airtel and MTN Group, two of the largest such firms in Africa, he applied artificial intelligence (AI) tools to help understand the consumer behaviour of 200 million mobile users in 20 countries, and designed ways of driving their consumption of products. He won…
-
Multi-omics features of immunogenic cell death in gastric cancer identified by combining single-cell sequencing analysis and machine learning
Abstract Gastric cancer (GC) is a prevalent malignancy with high mortality rates. Immunogenic cell death (ICD) is a unique form of programmed cell death that is closely linked to antitumor immunity and plays a critical role in modulating the tumor microenvironment (TME). Nevertheless, elucidating the precise effect of ICD on GC remains a challenging endeavour.…
-
Dual folate/biotin-decorated liposomes mediated delivery of methylnaphthazarin for anti-cancer activity
Abstract Chemotherapy is an effective strategy for mitigating the global challenge of cancer treatment, which often encounters drug resistance and negative side effects. Methylnaphthazarin (MNZ), a natural compound with promising anti-cancer properties, has been underexplored due to its poor aqueous solubility and low selectivity. This study introduces a novel approach to overcome these limitations by…
-
Chemical restriction of PU.1 genomic binding sites activates alternate gene networks
Blockade of primary genomic binding sites with small molecules causes redistribution of the transcription factor PU.1 to alternative binding sites; its transcriptional activity at these sites activates secondary gene networks that drive myeloid cell differentiation. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy…
-
Nutritional vitamin B12 regulates RAS/MAPK-mediated cell fate decisions through one-carbon metabolism
Abstract Vitamin B12 is an essential nutritional co-factor for the folate and methionine cycles, which together constitute one-carbon metabolism. Here, we show that dietary uptake of vitamin B12 modulates cell fate decisions controlled by the conserved RAS/MAPK signaling pathway in C. elegans. A bacterial diet rich in vitamin B12 increases vulval induction, germ cell apoptosis…
-
Deterministic responses of biodiversity to climate change through exotic species invasions
Abstract Biodiversity is increasingly threatened by local extinction under global climate change. This may reflect direct effects of climate on poorly adapted native species or increased impacts of exotic species in these conditions, but their relative importance is poorly understood. By examining global occurrence records of 142 plant species found in the Yangtze River Valley,…
-
Get Tomorrow’s Science And Tech News Today – Introducing The Prototype Newsletter
Share to Facebook Share to Twitter Share to Linkedin Five years before OpenAI rolled out ChatGPT, Google published a paper called “Attention Is All You Need” that laid out the fundamental transformer architecture underlying today’s AI boom. Five years before Moderna administered its first Covid mRNA vaccine, it dosed its first mRNA vaccine to a…
-
“Third state” of existence beyond life and death confirmed by study
In science fiction movies like Frankenstein and Re-Animator, human bodies are revived, existing in a strange state between life and death. While this may seem like pure fantasy, a recent study suggests that a “third state” of existence might actually be present in modern biology. According to the researchers, this third state occurs when the…