During the COVID-19 lockdown period, while working from home and sitting through endless Zoom meetings, we decided to add a late afternoon walk with our dogs to our calendars, while talking to each other over the phone. The menopause transition had begun for both of us, and we needed to create a space that we…

Abstract Determining structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here, we present reverse metabolomics as a discovery strategy, where MS/MS spectra are acquired from newly synthesized compounds and searched for in public metabolomics data to uncover phenotypic associations. To demonstrate the concept, we broadly synthesized and explored multiple classes…

The US Congress is crafting legislation for the Farm Bill, a multi-year law bolstered by Inflation Reduction Act (IRA) provisions. The IRA allocated US$15 billion for oversubscribed conservation initiatives, including $300 million for research needed for effective nature-based climate solutions. This crucial research funding is now under threat of reallocation (see go.nature.com/3rjx7uy), which would severely…

The research history of the auxin-binding protein ABP1 is convoluted and serves as an excellent example of nonlinear scientific progress. It was a promising extracellular auxin receptor in the long ‘Antique period’, roughly between the 1970s and 1990s. The ‘Dark Ages’ started in 2005 after interest shifted owing to the discovery of TIR1 as a…

arising from A. Weide et al. 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Flawed or faked research studies are fuelling a public mistrust in biomedical science (see, for example, Nature 619, 454–458; 2023). Public trust in research is essential for scientific progress because it correlates with funding and policy decisions, research participation and an openness to evolving evidence. I propose that independent ethics review boards could help to…