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Hypoblast from human pluripotent stem cells regulates epiblast development
Abstract Recently, several studies using cultures of human embryos together with single-cell RNA-seq (scRNA-seq) analyses have revealed differences between humans and mice, necessitating the study of human embryos 1-8. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation stage studies. Thus, recent efforts have focused on developing in vitro self-organising models…
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Guest edited collection: fungal evolution and diversity
There are 5 million fungal species. However, the discovery and classification of fungi are in high flux. Modern concepts indicate that the three kingdoms of “fungi” are Chromista, Fungi and Protozoa. Strong support for the wrong phylogeny can occur without correct analytical methods. In the current Collection we envisaged fungi representing extremely diverse and ancient…
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Quantifying spatial under-reporting disparities in resident crowdsourcing
Abstract Modern city governance relies heavily on crowdsourcing to identify problems such as downed trees and power lines. A major concern is that residents do not report problems at the same rates, with heterogeneous reporting delays directly translating to downstream disparities in how quickly incidents can be addressed. Here we develop a method to identify…
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Revisiting the use of structural similarity index in Hi-C
arising from S. Galan et al. 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It is time to talk openly about menopause in academia
During the COVID-19 lockdown period, while working from home and sitting through endless Zoom meetings, we decided to add a late afternoon walk with our dogs to our calendars, while talking to each other over the phone. The menopause transition had begun for both of us, and we needed to create a space that we…
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Risk factors for 5-year complications after midurethral sling surgery for stress urinary incontinence: a retrospective cohort study from Taiwan
Abstract Midurethral sling surgery is the current gold standard worldwide for stress urinary incontinence (SUI) surgery, with over 90% of surgeons worldwide using the midurethral sling for SUI between 2008 and 2018. However, concerns surround mesh-related adverse events associated with the midurethral sling. The decision to use the midurethral sling for surgical treatment has become…
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Reverse metabolomics for the discovery of chemical structures from humans
Abstract Determining structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here, we present reverse metabolomics as a discovery strategy, where MS/MS spectra are acquired from newly synthesized compounds and searched for in public metabolomics data to uncover phenotypic associations. To demonstrate the concept, we broadly synthesized and explored multiple classes…
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Nature-based climate solutions: align policy with science
The US Congress is crafting legislation for the Farm Bill, a multi-year law bolstered by Inflation Reduction Act (IRA) provisions. The IRA allocated US$15 billion for oversubscribed conservation initiatives, including $300 million for research needed for effective nature-based climate solutions. This crucial research funding is now under threat of reallocation (see go.nature.com/3rjx7uy), which would severely…
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Most scientists don’t enjoy writing grants. Here’s how to change that
Working in a group can give a sense of community to the process of writing grant applications.Credit: Getty What words come to mind when you think of preparing research proposals? The odds are that ‘excited’ and ‘happy’ are not among them. We regularly provide grant-writing training to academics of all career stages at Stanford University…
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ABP1’s new partners
The research history of the auxin-binding protein ABP1 is convoluted and serves as an excellent example of nonlinear scientific progress. It was a promising extracellular auxin receptor in the long ‘Antique period’, roughly between the 1970s and 1990s. The ‘Dark Ages’ started in 2005 after interest shifted owing to the discovery of TIR1 as a…