Abstract Zanthoxylum nitidum (Roxb.) is a commonly used traditional Chinese medicine. However, the collection and protection of wild germplasm resources of Z. nitidum are still insufficient, and there is limited research on its genetic diversity and fingerprint. In the present study, 15 simple sequence repeat (SSR) markers were developed by genotyping based on multiplexed shotgun…

Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by the accumulation of leukocytes and inflammatory mediators within the synovial tissue. Leukocyte counts are proposed to play a role in the pathogenesis of RA. However, the causality remains unclear. To investigate the causal relationship between various leukocytes and RA by implementing two-sample univariable Mendelian Randomization…

By Mark Broatch 25 Nov, 2023 11:30 PM4 mins to read The Master Builder by Alfonso Martinez Arias, Outlive by Dr Peter Attia and Wasteland by Oliver Franklin-Wallis. A Book of Noises: Notes On the Auraculous by Caspar Henderson (University of Chicago Press) Dividing the noises of creation into four – humans, other life, space…

GREEN BANK, W.Va. — It came from space, hurtling at tremendous speed: a mystery object, reddish, rocky, shaped like a cigar. Its velocity was so extreme it had to have come from somewhere far away, in the interstellar realm. The astronomers in Hawaii who spotted it in 2017 named it ‘Oumuamua, Hawaiian for “a messenger…

Breadcrumb Trail Links Columnists The end times depicted in Revelation, the last book of the Christian scriptures, are a cataclysm of vast destruction and glory. Author of the article: Bruce Tallman  •  Special to The London Free Press Published Nov 25, 2023  •  Last updated 3 hours ago  •  3 minute read Join the conversation The…

Abstract Climate change affects all ecosystems, but subterranean ecosystems are repeatedly neglected from political and public agendas. Cave habitats are home to unknown and endangered species, with low trait variability and intrinsic vulnerability to recover from human-induced disturbances. We studied the annual variability and cyclicity of temperatures in caves vis-à-vis surface in different climatic areas.…

Abstract Lumbar hernia is a rare lateral abdominal wall hernia. Various surgical repair strategies have been recorded, but there is currently no unified standard. A Chinese surgeon recently revealed a novel technique for treating primary lumbar hernia called retroperitoneal totally endoscopic prosthetic repair (R-TEP). We have made a further exploration of this method and successfully…

To the Editor: NOTCH1 is a transmembrane receptor in a highly conserved signaling pathway that controls cell fate decisions in various organisms and tissues. In contrast, its dysregulation is associated with developmental disorders transformation [1]. NOTCH1 is composed of extracellular and intracellular domains. Ligand binding of NOTCH1 extracellular domain leads to two consecutive cleavage steps…

Abstract It has been found that fractal-like patterns are present in the temporal structure of the variability of healthy biological rhythms, while pathology and disease lead to their deterioration. Interestingly, it has recently been suggested that these patterns in biological rhythms are related with each other, reflecting overall health or lack of it, due to…