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SSR molecular marker developments and genetic diversity analysis of Zanthoxylum nitidum (Roxb.) DC
Abstract Zanthoxylum nitidum (Roxb.) is a commonly used traditional Chinese medicine. However, the collection and protection of wild germplasm resources of Z. nitidum are still insufficient, and there is limited research on its genetic diversity and fingerprint. In the present study, 15 simple sequence repeat (SSR) markers were developed by genotyping based on multiplexed shotgun…
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Genetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by the accumulation of leukocytes and inflammatory mediators within the synovial tissue. Leukocyte counts are proposed to play a role in the pathogenesis of RA. However, the causality remains unclear. To investigate the causal relationship between various leukocytes and RA by implementing two-sample univariable Mendelian Randomization…
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The Year in Books: Our top science, philosophy and nature picks
By Mark Broatch 25 Nov, 2023 11:30 PM4 mins to read The Master Builder by Alfonso Martinez Arias, Outlive by Dr Peter Attia and Wasteland by Oliver Franklin-Wallis. A Book of Noises: Notes On the Auraculous by Caspar Henderson (University of Chicago Press) Dividing the noises of creation into four – humans, other life, space…
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What we actually know about aliens, according to science
GREEN BANK, W.Va. — It came from space, hurtling at tremendous speed: a mystery object, reddish, rocky, shaped like a cigar. Its velocity was so extreme it had to have come from somewhere far away, in the interstellar realm. The astronomers in Hawaii who spotted it in 2017 named it ‘Oumuamua, Hawaiian for “a messenger…
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Fred Allendorf: Science and Nature: Nobel Prize awarded for the COVID-19 vaccine
FRED ALLENDORF The 2023 Nobel Prize in Medicine was awarded recently to Katalin Karikó and Drew Weissman for their discoveries that enabled the development of mRNA (messenger RNA) vaccines for immunization against the coronavirus that causes COVID-19. According to the committee, “The vaccines have saved millions of lives and prevented severe disease in many more,…
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Tallman: World conflicts ‘last gasp’ of old regime, as humans evolve toward unity, harmony with nature
Breadcrumb Trail Links Columnists The end times depicted in Revelation, the last book of the Christian scriptures, are a cataclysm of vast destruction and glory. Author of the article: Bruce Tallman • Special to The London Free Press Published Nov 25, 2023 • Last updated 3 hours ago • 3 minute read Join the conversation The…
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Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats
Abstract In this study, the fraction extracted from turmeric powder with 50% ethanol and fractionated with n-hexane were administered to diet-induced NASH model rats. NASH model was prepared with SD rats by feeding an originally designed choline-deficient, high-fat, high-fructose (HFF-CD) diet for 10 weeks. To the HFF-CD diet, hexane fraction and 50% ethanol fraction after hexane…
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Structured dataset of human-machine interactions enabling adaptive user interfaces
Abstract This article introduces a dataset of human-machine interactions collected in a controlled and structured manner. The aim of this dataset is to provide insights into user behavior and support the development of adaptive Human-Machine Interfaces (HMIs). The dataset was generated using a custom-built application that leverages formally defined User Interfaces (UIs). The resulting interactions…
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Cities and regions tackle climate change mitigation but often focus on less effective solutions
Abstract Although the potential for cities and regions to contribute to global mitigation efforts is widely acknowledged, there is little evidence on the effectiveness of subnational mitigation strategies. Here we address this gap through a systematic review of 234 quantitative mitigation case studies. We use a meta-analytical approach to estimate expected greenhouse gas emissions reductions…
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Phylogenetic structure of body shape in a diverse inland ichthyofauna
Abstract Body shape is a fundamental metric of animal diversity affecting critical behavioral and ecological dynamics and conservation status, yet previously available methods capture only a fraction of total body-shape variance. Here we use structure-from-motion (SFM) 3D photogrammetry to generate digital 3D models of adult fishes from the Lower Mississippi Basin, one of the most…