Abstract When searching for the ideal molecule to fill a particular functional role (for example, a medicine), the difference between success and failure can often come down to a single atom1. Replacing an aromatic carbon atom with a nitrogen atom would be enabling in the discovery of potential medicines2, but only indirect means exist to make…

Saleemul Huq, a pioneering climate scientist from Bangladesh who pushed to get the world to understand, pay for and adapt to worsening warming impacts on poorer nations, died of cardiac arrest Saturday. He was 71. “Saleem always focused on the poor and marginalized, making sure that climate change was about people, their lives, health and…

Historians and archaeologists have, over centuries, explored the mysteries behind the Great Sphinx of Giza: What did it originally look like? What was it designed to represent? What was its original name? But less attention has been paid to a foundational, and controversial, question: What was the terrain the Ancient Egyptians came across when they…

I have always been passionate about nature and its perfect synchrony and balance. When I was 6 years old, I received a mini microscope, as a Christmas gift; that changed my view of the world and defined my professional path. Seeing particles that were invisible to human eyes led me to an interesting observation: Every…

One April morning, medical student Asjad Yousif Abdalrahman Bushra awoke to the sound of bombs exploding in Khartoum. He was planning to attend a funeral that day and then start preparations for celebrating Eid. But war had erupted between the Sudanese army and a paramilitary force called the Rapid Support Forces. As of 22 September,…

Abstract We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting…

Bletchley Park, home to the United Kingdom’s wartime code-breaking team, is hosting this week’s AI safety summit. Delegates need to work towards regulatory transparency in the technology’s underlying data and models.Credit: Justin Tallis/AFP/Getty How to maximize the benefits of artificial intelligence (AI) while minimizing its harms is a worldwide preoccupation. This week, the spotlight is…

Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. Credit: Mark Garlick/Science Photo Library Dinosaurs might have met a dusty end Dust might have been responsible for the deadly dinosaur-killing global winter that came after an asteroid slammed into Earth 66 million years ago. Climate…

Abstract Foodborne diseases (FBDs) are a major public health concern, especially in Sub-Saharan African (SSA) countries, such as Ghana, where poor food handling practices (FHPs) are prevalent. To estimate the pooled proportion of good FHPs and the associated factors among Ghanaian food handlers, this systematic review and meta-analysis was conducted to aid scholars, practitioners and…

Abstract Studies on the association between depression and self-reported endometriosis are limited, and further studies are required to investigate this association. Data were collected from the National Health and Nutrition Examination Survey database (2005–2006). Based on the inclusion and exclusion criteria, 100 participants with self-reported endometriosis and 1295 participants without self-reported endometriosis were included, representing…