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Prognostic visualization model for primary pulmonary sarcoma: a SEER-based study
Abstract Primary pulmonary sarcoma (PPS) is a rare and poor prognostic malignancy that results from current clinical studies are lacking. Our study aimed to investigate the prognostic factors of PPS and to construct a predictive nomogram that predict the overall survival (OS) rate. We extracted data on patients diagnosed with PPS from 2010 to 2019…
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Correlation analysis of obesity phenotypes with leptin and adiponectin
Abstract Obesity can be categorized as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). However, individuals with MHO are characterized by the absence of metabolic syndrome (MS) and appear to have lower inflammation levels compared to MUO. This study aimed to investigate the association of obesity phenotypes with leptin (LEP) and adiponectin (ADP). According…
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Physician–scientist trainees with parenting responsibilities need financial and childcare support
Physician–scientists who become parents during their long period of training need additional funding and support for lactation, childcare and healthcare, to ensure an equitable workforce. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy or subscribe /* style specs start */ style{display:none!important}.LiveAreaSection-193358632 *{align-content:stretch;align-items:stretch;align-self:auto;animation-delay:0s;animation-direction:normal;animation-duration:0s;animation-fill-mode:none;animation-iteration-count:1;animation-name:none;animation-play-state:running;animation-timing-function:ease;azimuth:center;backface-visibility:visible;background-attachment:scroll;background-blend-mode:normal;background-clip:borderBox;background-color:transparent;background-image:none;background-origin:paddingBox;background-position:0 0;background-repeat:repeat;background-size:auto…
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Deep asleep? You can still follow simple commands, study finds
Sleep studies often involve measuring the electrical activity in a person’s brain using electroencephalography.Credit: Getty Scientists once considered sleep to be like a shade getting drawn over a window between the brain and the outside world: when the shade is closed, the brain stops reacting to outside stimuli. A study published on 12 October in…
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Long COVID research risks losing momentum – we need a moonshot
COVID-19 offers researchers their best chance yet to understand, and find treatments for, a chronic illness associated with an infectious disease. Infection-associated chronic conditions are not widely understood. Partly because of this, people who develop such conditions often face scepticism and stigma; health-care systems are ill-equipped to deal with them; and cases are likely to…
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AI-powered structure-based drug design inspired by the lock-and-key model
Inspired by the classic lock-and-key model and advances in equivariant deep network design, we present a structure-based drug design model, SurfGen, which uses two types of equivariant graph neural networks to learn on protein surfaces and geometric structures to directly design small-molecule drugs. This is a preview of subscription content, access via your institution Access…
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How the current bird flu strain evolved to be so deadly
A pair of cormorants thought to have died from H5N1 bird flu, found washed up on a beach in Chile earlier this year.Credit: Martin Bernetti/AFP via Getty Researchers studying the evolution of the bird flu virus over the past 18 years have shown how the strain currently circulating worldwide, an extremely deadly form of the…
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Daily briefing: COVID drug helps to bring back sense of smell
Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. A new drug can alleviate loss of smell and taste caused by COVID-19.Credit: Angela Weiss/AFP via Getty COVID drug helps bring back sense of smell Clinical-trial data suggest that an antiviral pill called ensitrelvir is among…
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The centennial of the planetarium
The first planetarium projector was completed 100 years ago, providing the public with an unparalleled view of the night sky. The International Planetarium Society is marking this major anniversary with celebratory events across the globe. The history of planetariums starts with the desire of humankind to reproduce the unique beauty of the night sky. Marvellous…
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How to share data — not just equally, but equitably
Mexico City’s people have trusted researchers with their medical histories.Credit: Cristopher Rogel Blanquet/Getty Two decades ago, scientists asked more than 150,000 people living in Mexico City to provide medical data for research. Each participant gave time, blood and details of their medical history. For the researchers, who were based at the National Autonomous University of…