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mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
Abstract We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting…
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Why the UK-led global AI summit is missing the point
Bletchley Park, home to the United Kingdom’s wartime code-breaking team, is hosting this week’s AI safety summit. Delegates need to work towards regulatory transparency in the technology’s underlying data and models.Credit: Justin Tallis/AFP/Getty How to maximize the benefits of artificial intelligence (AI) while minimizing its harms is a worldwide preoccupation. This week, the spotlight is…
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Daily briefing: Deep-diving seals led scientists to an undiscovered underwater canyon
Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. Credit: Mark Garlick/Science Photo Library Dinosaurs might have met a dusty end Dust might have been responsible for the deadly dinosaur-killing global winter that came after an asteroid slammed into Earth 66 million years ago. Climate…
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A systematic review and meta-analysis of food handling practices in Ghana vis-a-vis the associated factors among food handlers during 2009 and 2022
Abstract Foodborne diseases (FBDs) are a major public health concern, especially in Sub-Saharan African (SSA) countries, such as Ghana, where poor food handling practices (FHPs) are prevalent. To estimate the pooled proportion of good FHPs and the associated factors among Ghanaian food handlers, this systematic review and meta-analysis was conducted to aid scholars, practitioners and…
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Association between depression and endometriosis using data from NHANES 2005–2006
Abstract Studies on the association between depression and self-reported endometriosis are limited, and further studies are required to investigate this association. Data were collected from the National Health and Nutrition Examination Survey database (2005–2006). Based on the inclusion and exclusion criteria, 100 participants with self-reported endometriosis and 1295 participants without self-reported endometriosis were included, representing…
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CHIT1-positive microglia drive motor neuron aging in the primate spinal cord
Abstract Aging is a critical factor in spinal cord-associated disorders1, yet aging-specific mechanisms underlying this relationship remain poorly understood. To address this knowledge gap, we combined single-nucleus RNA sequencing with behavioral and neurophysiological analysis in non-human primates (NHPs). We identified motor neuron senescence and neuroinflammation with microglial hyperactivation as intertwined hallmarks of spinal cord aging.…
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Characterization of lithium (Li) treated human cortical spheroids (hCS)
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Mitigating ghost fishing
Abandoned, lost and discarded fishing gear, often informally called ‘ghost gear’, accounts for 10% of global ocean plastic pollution. It is also the deadliest form of marine plastic, with discarded nets, hooks and trawlers entangling and killing marine life. Such ghost fishing represents largely unaccounted ecosystem damage and food waste. This is a preview of subscription…
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Blood-sucking fish had flesh-eating ancestors
Jurassic lampreys (artist’s impression) used their toothed suckers to consume the flesh of their prey, a strategy that allowed them to grow larger than their ancestors.Credit: Heming Zhang Under the water on an Earth ruled by dinosaurs, an eerie-looking fish senses its prey. A sudden dart, and it latches onto its victim with a powerful…
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Open-access reformers launch next bold publishing plan
The group behind the radical open-access initiative Plan S has announced its next big plan to shake up research publishing — and this one could be bolder than the first. It wants all versions of an article and its associated peer-review reports to be published openly from the outset, without authors paying any fees, and…