Abstract Here we present the Digital Brain (DB)—a platform for simulating spiking neuronal networks at the large neuron scale of the human brain on the basis of personalized magnetic resonance imaging data and biological constraints. The DB aims to reproduce both the resting state and certain aspects of the action of the human brain. An…

Abstract Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, particularly in realistic cell geometries. Here we present Spatial Modeling Algorithms for Reactions and Transport (SMART), a software package that takes in…

Nature’s 2023 survey of postdoctoral researchers identified a notable gap between industry and academia. Although industry postdocs remain in the minority — only 7% of the 3,838 respondents from around the world reported working in an industrial setting — they reported greater satisfaction and tended to be better compensated. Nearly one-quarter of postdocs in industry…

Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. Australopithecus afarensis did not have the lengthened Achilles tendon and shortened muscle fibres that benefit modern runners.Credit: Christian Jegou/Science Photo Library These legs were made for running Modern humans could outrun our ancient human relatives Australopithecus…

Fury: The Power of Nature is a new exhibit at the Tellus Science Museum in Cartersville, Ga. The exhibit opened Dec. 7 and will run through January 4, 2026. Curatorial Coordinator, Rebecca Melsheimer said various objects from the National Oceanic and Atmospheric Administration (NOAA) Marine Debris Program, NOAA Heritage, and the Uncharted Supply Company were…

Scientists have long agreed that early humans mated with Neanderthals, but a pair of recent studies have shed light on when exactly this DNA mixing occurred. Such a revelation could help geneticists learn more about our past — and crucially, our future. The studies, published Dec. 12 in the journals Science and Nature, provide information…

Open-access journal eLife has been in the vanguard of experimental publishing since its founding in 2012.Credit: Nature The open-access journal eLife is facing upset after the news that the journal will lose its impact factor — a controversial metric based on citations that is often used as shorthand for quality. Clarivate, the London-based analytics firm…

Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. Hydroxychloroquine is used to treat malaria and was tested as a treatment for COVID-19.Credit: George Frey/AFP via Getty Controversial COVID study retracted A study that stoked enthusiasm for the now-disproven idea that the malaria drug hydroxychloroquine…

President-elect Donald Trump has promised to increase US fossil-fuel production.Credit: Matt Smith/Alamy Washington DC If Donald Trump follows through on promises for his second term as US president, he will unleash sweeping changes in climate policy within hours or days of his inauguration on 20 January. Among the shifts, he could pull the United States…

Military spending is fuelling wars such as the one in Sudan, forcing people to flee.Credit: Luis Tato/AFP/Getty The fall of the regime of former Syrian president Bashar al-Assad, which brought widespread joy and optimism, was a rare and welcome development in what has mostly been another devastating year of violence and conflict around the world.…