Abstract Background Although polygenic risk scores (PRSs) are expected to be helpful in precision medicine, it remains unclear whether high-PRS groups are more likely to benefit from preventive interventions for diseases. Recent methodological advancements enable us to predict treatment effects at the individual level. Methods We employed causal forest to explore the relationship between PRSs…

In a bamboo forest, a giant panda chomps on some bamboo leaves—but for how long? While these cuddly looking bears have few natural predators, they remain vulnerable.1 Today, less than 2,000 giant pandas live in the wild, and another 600 survive in zoos and protected habitats around the world. As loss of this umbrella species…

Abstract Land-use change such as the conversion of natural habitat to agricultural land has been a major driver of global biodiversity loss, prompting efforts at biodiversity restoration. However, restoration measures in certain areas can shift the detrimental biodiversity impacts elsewhere through the outsourcing of agri-food supply chains to biodiverse regions. This study examines the link…

In a bamboo forest, a giant panda chomps on some bamboo leaves—but for how long? While these cuddly looking bears have few natural predators, they remain vulnerable.1 Today, less than 2,000 giant pandas live in the wild, and another 600 survive in zoos and protected habitats around the world. As loss of this umbrella species…

Abstract The placenta plays a crucial role in protecting the fetus from environmental harm and supports the development of its brain. In fact, compromised placental function could predispose an individual to neurodevelopmental disorders. Placental epigenetic modifications, including DNA methylation, could be considered a proxy of placental function and thus plausible mediators of the association between…

In a bamboo forest, a giant panda chomps on some bamboo leaves—but for how long? While these cuddly looking bears have few natural predators, they remain vulnerable.1 Today, less than 2,000 giant pandas live in the wild, and another 600 survive in zoos and protected habitats around the world. As loss of this umbrella species…

Abstract The combined gravity of biodiversity loss and climate change keeps increasing. As the approaching catastrophe has never looked so alarming, the amount of scientific knowledge about the bioclimatic crisis is still rising exponentially. Here we reflect on how researchers in ecology or climate science behave amid this crisis. In face of the disproportionality between…

Abstract Climate assessments have largely overlooked the radiative effect of anthropogenic coarse particulate matter (PMcoarse, with an aerodynamic diameter between 2.5 and 10 µm) in China. Despite its similar mass concentration to fine particulate matter (PM2.5), anthropogenic sources of PMcoarse in China have been much less studied and typically underrepresented in models. Here, we present a…

Abstract Climate assessments have largely overlooked the radiative effect of anthropogenic coarse particulate matter (PMcoarse, with an aerodynamic diameter between 2.5 and 10 µm) in China. Despite its similar mass concentration to fine particulate matter (PM2.5), anthropogenic sources of PMcoarse in China have been much less studied and typically underrepresented in models. Here, we present a…

Abstract Climate assessments have largely overlooked the radiative effect of anthropogenic coarse particulate matter (PMcoarse, with an aerodynamic diameter between 2.5 and 10 µm) in China. Despite its similar mass concentration to fine particulate matter (PM2.5), anthropogenic sources of PMcoarse in China have been much less studied and typically underrepresented in models. Here, we present a…