Abstract Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve healthspan. Two of the most broadly used anti-aging interventions that are effective in organisms from yeast to mammals are calorie restriction (CR) and rapamycin (RM) treatment. To identify the…

Investigators the Yale Department of Psychiatry investigated the genetic profiles of more than 1 million participants enrolled in multiple cohorts around the world. Leveraging this large dataset, they uncovered more than 100 genes associated with anxiety. The results were published in Nature Genetics. Anxiety disorders and symptoms affect many individuals with a negative impact on…

Sign up for the Smarter Faster newsletter A weekly newsletter featuring the biggest ideas from the smartest people Notice: JavaScript is required for this content. Sara Imari Walker is a professor of physics at Arizona State University and the author of a new book Life as No One Knows It: The Physics of Life’s Emergence.…

Summary: Researchers at Kobe University have developed a novel test substrate that allows the first-ever measurement of the speed and mechanism of a fungal enzyme that breaks down wood, paving the way for improved biofuel and biochemical production. Estimated reading time: 5 minutes In an advance for biofuel and biochemical research, scientists at Kobe University…

McGill University researchers have developed a light-driven process that uses sunlight to convert methane and carbon dioxide into valuable chemicals, such as green methanol and carbon monoxide. This breakthrough could help reduce greenhouse gases and support more sustainable industrial practices. A chemical process developed by the McGill team could hasten progress toward carbon neutrality. Researchers…

A Chinese scientist recently came up with an interesting idea that could reduce carbon pollution worldwide by 28%, but it’s a bit of a long shot — at least for now. Ling Yao, a remote sensing scientist at the Chinese Academy of Sciences and the study’s lead author, shared the concept in an American Geophysical…

After a decade building quantum-computing hardware, Jacques Carolan decided he needed a change. “I wanted to work on technologies that were more directly related to human health,” he says. So in 2021, he pivoted to neuroscience with the aim of building optical technologies to understand the brain. Last year, another opportunity turned Carolan’s head. The…

To an outside observer, Olubayo Adekanmbi’s career in telecommunications epitomized success. At Airtel and MTN Group, two of the largest such firms in Africa, he applied artificial intelligence (AI) tools to help understand the consumer behaviour of 200 million mobile users in 20 countries, and designed ways of driving their consumption of products. He won…

Abstract Gastric cancer (GC) is a prevalent malignancy with high mortality rates. Immunogenic cell death (ICD) is a unique form of programmed cell death that is closely linked to antitumor immunity and plays a critical role in modulating the tumor microenvironment (TME). Nevertheless, elucidating the precise effect of ICD on GC remains a challenging endeavour.…

Abstract Chemotherapy is an effective strategy for mitigating the global challenge of cancer treatment, which often encounters drug resistance and negative side effects. Methylnaphthazarin (MNZ), a natural compound with promising anti-cancer properties, has been underexplored due to its poor aqueous solubility and low selectivity. This study introduces a novel approach to overcome these limitations by…