Blockade of primary genomic binding sites with small molecules causes redistribution of the transcription factor PU.1 to alternative binding sites; its transcriptional activity at these sites activates secondary gene networks that drive myeloid cell differentiation. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy…

Abstract Vitamin B12 is an essential nutritional co-factor for the folate and methionine cycles, which together constitute one-carbon metabolism. Here, we show that dietary uptake of vitamin B12 modulates cell fate decisions controlled by the conserved RAS/MAPK signaling pathway in C. elegans. A bacterial diet rich in vitamin B12 increases vulval induction, germ cell apoptosis…

Abstract Biodiversity is increasingly threatened by local extinction under global climate change. This may reflect direct effects of climate on poorly adapted native species or increased impacts of exotic species in these conditions, but their relative importance is poorly understood. By examining global occurrence records of 142 plant species found in the Yangtze River Valley,…

Share to Facebook Share to Twitter Share to Linkedin Five years before OpenAI rolled out ChatGPT, Google published a paper called “Attention Is All You Need” that laid out the fundamental transformer architecture underlying today’s AI boom. Five years before Moderna administered its first Covid mRNA vaccine, it dosed its first mRNA vaccine to a…

In science fiction movies like Frankenstein and Re-Animator, human bodies are revived, existing in a strange state between life and death. While this may seem like pure fantasy, a recent study suggests that a “third state” of existence might actually be present in modern biology.  According to the researchers, this third state occurs when the…

There are some species that have persevered through mass extinctions, climate shifts and the relentless pressures of evolution. Others, with their centuries-long lifespans, have outlasted predators, endured environmental shifts and witnessed more of Earth’s history than humans could ever experience. Such species’ amazingly long lifespans could, interestingly, mean one thing—they probably don’t see time as…

Since time immemorial, humanity has always pondered the subject of life and death. While the concept of life beyond death remains a moot point, with no substantial proof, in general life and death are considered antithetical. Death is viewed as the complete cessation of life. However, a new study now suggests that life and death…

Physicists have nailed a fiendishly difficult measurement — the mass of the fundamental particle the W boson. The result, from the CMS experiment at the Large Hadron Collider (LHC), is in line with the predictions of the standard model, and pours cold water on an anomaly in the W boson mass that surfaced in 2022.…

Institutional filing cabinets hoard tens of thousands of evaluation studies.Credit: HUM Images/Universal Images Group/Getty On 22 and 23 September, world leaders will meet in New York City at an unusual Summit of the Future. Devised by United Nations secretary-general António Guterres, the meeting aims to bolster global efforts to build a better world. Guterres is…

Suppose you’ve outgrown your beginner pair of binoculars and want to upgrade to a pair with better optics, wider objectives and stronger magnification. In that case, we think the Celestron Nature DX 12×56 are a perfect fit that won’t break the bank. And the good news is you can pick them up for less than…