Investigators the Yale Department of Psychiatry investigated the genetic profiles of more than 1 million participants enrolled in multiple cohorts around the world. Leveraging this large dataset, they uncovered more than 100 genes associated with anxiety. The results were published in Nature Genetics. Anxiety disorders and symptoms affect many individuals with a negative impact on…

Abstract Geothermal features in Antarctica provide favorable conditions for diverse microorganisms, yet their genomic diversity remains poorly understood. Here, we present an integrated dataset comprising PacBio HiFi and Hi-C metagenomic sequencing, along with single-cell amplified genomes (SAGs) from two high-altitude geothermal sites, Mount Melbourne and Mount Rittmann, in Antarctica. The long-read HiFi sequencing, coupled with…

Sign up for the Smarter Faster newsletter A weekly newsletter featuring the biggest ideas from the smartest people Notice: JavaScript is required for this content. Sara Imari Walker is a professor of physics at Arizona State University and the author of a new book Life as No One Knows It: The Physics of Life’s Emergence.…

Summary: Researchers at Kobe University have developed a novel test substrate that allows the first-ever measurement of the speed and mechanism of a fungal enzyme that breaks down wood, paving the way for improved biofuel and biochemical production. Estimated reading time: 5 minutes In an advance for biofuel and biochemical research, scientists at Kobe University…

McGill University researchers have developed a light-driven process that uses sunlight to convert methane and carbon dioxide into valuable chemicals, such as green methanol and carbon monoxide. This breakthrough could help reduce greenhouse gases and support more sustainable industrial practices. A chemical process developed by the McGill team could hasten progress toward carbon neutrality. Researchers…

A Chinese scientist recently came up with an interesting idea that could reduce carbon pollution worldwide by 28%, but it’s a bit of a long shot — at least for now. Ling Yao, a remote sensing scientist at the Chinese Academy of Sciences and the study’s lead author, shared the concept in an American Geophysical…

To an outside observer, Olubayo Adekanmbi’s career in telecommunications epitomized success. At Airtel and MTN Group, two of the largest such firms in Africa, he applied artificial intelligence (AI) tools to help understand the consumer behaviour of 200 million mobile users in 20 countries, and designed ways of driving their consumption of products. He won…

Abstract Gastric cancer (GC) is a prevalent malignancy with high mortality rates. Immunogenic cell death (ICD) is a unique form of programmed cell death that is closely linked to antitumor immunity and plays a critical role in modulating the tumor microenvironment (TME). Nevertheless, elucidating the precise effect of ICD on GC remains a challenging endeavour.…

Abstract Chemotherapy is an effective strategy for mitigating the global challenge of cancer treatment, which often encounters drug resistance and negative side effects. Methylnaphthazarin (MNZ), a natural compound with promising anti-cancer properties, has been underexplored due to its poor aqueous solubility and low selectivity. This study introduces a novel approach to overcome these limitations by…

Blockade of primary genomic binding sites with small molecules causes redistribution of the transcription factor PU.1 to alternative binding sites; its transcriptional activity at these sites activates secondary gene networks that drive myeloid cell differentiation. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy…