image:  Jessica Tierney is a paleoclimatologist at the University of Arizona and a co-author of the new paper.  view more  Credit: University of Arizona Published in the journal Science, the study presents a curve of global mean surface temperature that reveals Earth’s temperature has varied more than previously thought over much of the Phanerozoic Eon a…

Credit: Pixabay/CC0 Public Domain Lavas from hotspots—whether erupting in Hawaii, Samoa or Iceland—likely originate from a worldwide, uniform reservoir in Earth’s mantle, according to an evaluation of volcanic hotspots published in Nature Geoscience. The findings indicate Earth’s mantle is far more chemically homogenous than scientists previously thought—and that lavas only acquire their unique chemical “flavors”…

Abstract This study helps in managing waste glass and greening the environment by incorporating laboratory waste glass into mortar production to make an eco-friendly shielding material against gamma rays. The efficiency of using waste glass powder as a cement replacement or addition in mortar production was studied by using two waste glass sizes: micro glass…

Abstract New molecular technologies have helped unveil previously unexplored facets of the genome beyond the canonical proteome, including microproteins and short ORFs, products of alternative splicing, regulatory non-coding RNAs, as well as transposable elements, cis-regulatory DNA, and other highly repetitive regions of DNA. In this Review, we highlight what is known about this ‘hidden genome’…

Abstract Determining causal relationships between environmental change and early animal evolution has been limited by our lack of a robust temporal framework for the Ediacaran Period (635-539 million years ago). Here we present six new radioisotopic age constraints from the Sultanate of Oman, which furnish a quantitative temporal framework for biogeochemical changes associated with animal…

Abstract Despite the increasing relevance of temperature overshoot and the rather ambitious country pledges on Afforestation/Reforestation globally, the mitigation potential and the Earth system responses to large-scale non-idealized Afforestation/Reforestation patterns under a high overshoot scenario remain elusive. Here, we develop an ambitious Afforestation/Reforestation scenario by harnessing 1259 Integrated Assessment Model scenarios, restoration potential maps, and…

Abstract Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve healthspan. Two of the most broadly used anti-aging interventions that are effective in organisms from yeast to mammals are calorie restriction (CR) and rapamycin (RM) treatment. To identify the…

Investigators the Yale Department of Psychiatry investigated the genetic profiles of more than 1 million participants enrolled in multiple cohorts around the world. Leveraging this large dataset, they uncovered more than 100 genes associated with anxiety. The results were published in Nature Genetics. Anxiety disorders and symptoms affect many individuals with a negative impact on…

Abstract Geothermal features in Antarctica provide favorable conditions for diverse microorganisms, yet their genomic diversity remains poorly understood. Here, we present an integrated dataset comprising PacBio HiFi and Hi-C metagenomic sequencing, along with single-cell amplified genomes (SAGs) from two high-altitude geothermal sites, Mount Melbourne and Mount Rittmann, in Antarctica. The long-read HiFi sequencing, coupled with…

Abstract Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological Proteolysis-Targeting Chimera’ (bioPROTAC). Here we employ an analogous approach where the target protein is recruited directly to a human…