Effect of oral nutrition supplements on anthropometric and functional parameters among community-dwelling older adults: a systematic review and meta-analysis of randomized controlled trials


  • Kehoe L, Walton J, Flynn A. Nutritional challenges for older adults in Europe: current status and future directions. Proceedings of the Nutrition Society. 2019;78(2):221–33.

    Article 

    Google Scholar 

  • Martins AD, et al. Effects of exercise programs on phase angle in older adults: A systematic review and meta-analysis. Arch Gerontol Geriatr. 2022;103: 104787.

    Article 

    Google Scholar 

  • Ophey A, et al. Cognition in People Aged 80 Years and Older: Determinants and Predictors of Change from a Population-Based Representative Study in Germany. J Frailty Aging. 2023;12(3):189–97.

    Article 
    CAS 

    Google Scholar 

  • Christensen K, et al. Ageing populations: the challenges ahead. The lancet. 2009;374(9696):1196–208.

    Article 

    Google Scholar 

  • Konda S, Giri P. Prevalence of malnutrition and its determinants in an elderly people in South India. Int J Community Med Public Health. 2018;5(8):3570–6.

    Article 

    Google Scholar 

  • Maseda A, et al. Health determinants of nutritional status in community-dwelling older population: the VERISAÚDE study. Public Health Nutr. 2016;19(12):2220–8.

    Article 
    PubMed Central 

    Google Scholar 

  • Sripongpunkul C, et al. Factors associated with unintentional weight loss among older adults in a geriatric outpatient clinic of university hospital. PLoS ONE. 2021;16(11): e0260233.

    Article 
    CAS 
    PubMed Central 

    Google Scholar 

  • Ferrari L, et al. Feasibility and effectiveness of a 6-month, home-based, resistance exercise delivered by a remote technological solution in healthy older adults. Arch Gerontol Geriatr. 2024;127: 105559.

    Article 

    Google Scholar 

  • Maier AB, et al. Strengthening Muscle Health of Community-Dwelling Older Adults in Singapore: Evidence Towards Clinical Implementation. J Frailty Aging. 2023;12(4):258–66.

    Article 
    CAS 

    Google Scholar 

  • Lorbergs A, et al. Nutrition and physical activity clinical practice guidelines for older adults living with frailty. J Frailty Aging. 2022;11(1):3–11.

    Article 
    CAS 

    Google Scholar 

  • Mayo A, et al. Can an active lifestyle offset the relationship that poor lifestyle behaviours have on frailty? Arch Gerontol Geriatr. 2024;127: 105556.

    Article 
    CAS 

    Google Scholar 

  • Amarya, S., K. Singh, and M. Sabharwal, Ageing process and physiological changes, in Gerontology. 2018. IntechOpen.

  • Saghafi-Asl M, et al. Geriatric nutritional risk index as a simple tool for assessment of malnutrition among geriatrics in Northwest of Iran: comparison with mini nutritional assessment. Aging Clin Exp Res. 2018;30:1117–25.

    Article 

    Google Scholar 

  • Gall M, Harmer J, Wanstall H. Prescribing of oral nutritional supplements in Primary Care: can guidelines supported by education improve prescribing practice? Clin Nutr. 2001;20(6):511–5.

    Article 
    CAS 

    Google Scholar 

  • Cramer JT, et al. Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial. J Am Med Dir Assoc. 2016;17(11):1044–55.

    Article 

    Google Scholar 

  • Elia M, et al. A systematic review of the cost and cost effectiveness of using standard oral nutritional supplements in community and care home settings. Clin Nutr. 2016;35(1):125–37.

    Article 
    CAS 

    Google Scholar 

  • Seguy D, et al. Compliance to oral nutritional supplementation decreases the risk of hospitalisation in malnourished older adults without extra health care cost: Prospective observational cohort study. Clin Nutr. 2020;39(6):1900–7.

    Article 
    CAS 

    Google Scholar 

  • Hamirudin AH, Charlton K, Walton K. Outcomes related to nutrition screening in community living older adults: A systematic literature review. Arch Gerontol Geriatr. 2016;62:9–25.

    Article 

    Google Scholar 

  • Poscia A, et al. Effectiveness of nutritional interventions addressed to elderly persons: umbrella systematic review with meta-analysis. Eur J Pub Health. 2018;28(2):275–83.

    Article 

    Google Scholar 

  • Deutz NE, et al. Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial. Clin Nutr. 2016;35(1):18–26.

    Article 

    Google Scholar 

  • Deutz NE, et al. Reduced mortality risk in malnourished hospitalized older adult patients with COPD treated with a specialized oral nutritional supplement: sub-group analysis of the NOURISH study. Clin Nutr. 2021;40(3):1388–95.

    Article 
    CAS 

    Google Scholar 

  • Stratton RJ, Hébuterne X, Elia M. A systematic review and meta-analysis of the impact of oral nutritional supplements on hospital readmissions. Ageing Res Rev. 2013;12(4):884–97.

    Article 

    Google Scholar 

  • McGowan L, et al. The impact of oral rehabilitation coupled with healthy dietary advice on the nutritional status of adults: A systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2020;60(13):2127–47.

    Article 
    CAS 

    Google Scholar 

  • Wright J, Baldwin C. Oral nutritional support with or without exercise in the management of malnutrition in nutritionally vulnerable older people: A systematic review and meta-analysis. Clin Nutr. 2018;37(6):1879–91.

    Article 

    Google Scholar 

  • Chew STH, et al. Impact of specialized oral nutritional supplement on clinical, nutritional, and functional outcomes: A randomized, placebo-controlled trial in community-dwelling older adults at risk of malnutrition. Clin Nutr. 2021;40(4):1879–92.

    Article 
    CAS 

    Google Scholar 

  • Li M, et al. Effectiveness of oral nutritional supplements on older people with anorexia: A systematic review and meta-analysis of randomized controlled trials. Nutrients. 2021;13(3):1–24.

    Article 

    Google Scholar 

  • Liberati A, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009;151(4):W65–94.

    Article 

    Google Scholar 

  • Thomson KH, et al. Effectiveness and cost-effectiveness of oral nutritional supplements in frail older people who are malnourished or at risk of malnutrition: a systematic review and meta-analysis. The Lancet Healthy Longevity. 2022;3(10):e654–66.

    Article 

    Google Scholar 

  • Higgins, J.P. and S. Green, Cochrane handbook for systematic reviews of interventions. 2008.

  • Blondal B, et al. HOMEFOOD randomised trial–Six-month nutrition therapy improves quality of life, self-rated health, cognitive function, and depression in older adults after hospital discharge. Clinical nutrition ESPEN. 2022;48:74–81.

    Article 
    CAS 

    Google Scholar 

  • Bunout D, et al. The impact of nutritional supplementation and resistance training on the health functioning of free-living Chilean elders: results of 18 months of follow-up. J Nutr. 2001;131(9):2441S–2446S.

    Article 
    CAS 

    Google Scholar 

  • Lipschitz DA, et al. Nutritional evaluation and supplementation of elderly subjects participating in a “meals on wheels” program. J Parenter Enter Nutr. 1985;9(3):343–7.

    Article 
    CAS 

    Google Scholar 

  • Sugawara K, et al. Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD. Respir Med. 2010;104(12):1883–9.

    Article 

    Google Scholar 

  • Bonnefoy M, et al. Efficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: a randomised study. J Nutr Health Aging. 2012;16:370–7.

    Article 
    CAS 

    Google Scholar 

  • Woo J, et al. Randomized controlled trial of exercise and nutrition supplementation on physical and cognitive function in older Chinese adults aged 50 years and older. J Am Med Dir Assoc. 2020;21(3):395–403.

    Article 

    Google Scholar 

  • Bruce D, et al. Nutritional supplements after hip fracture: poor compliance limits effectiveness. Clin Nutr. 2003;22(5):497–500.

    Article 
    CAS 

    Google Scholar 

  • Neelemaat F, et al. Post-discharge nutritional support in malnourished elderly individuals improves functional limitations. J Am Med Dir Assoc. 2011;12(4):295–301.

    Article 

    Google Scholar 

  • Gazzotti C, et al. Prevention of malnutrition in older people during and after hospitalisation: results from a randomised controlled clinical trial. Age Ageing. 2003;32(3):321–5.

    Article 

    Google Scholar 

  • Terp R, et al. A nutritional intervention program improves the nutritional status of geriatric patients at nutritional risk—a randomized controlled trial. Clin Rehabil. 2018;32(7):930–41.

    Article 

    Google Scholar 

  • Tieland M, et al. Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2012;13(8):720–6.

    Article 

    Google Scholar 

  • De Jong N, et al. Dietary supplements and physical exercise affecting bone and body composition in frail elderly persons. Am J Public Health. 2000;90(6):947.

    Article 
    PubMed Central 

    Google Scholar 

  • Lin, C.-C., et al., Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adults: An open-label, parallel-group study. 2021.

  • Ng TP, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med. 2015;128(11):1225–1236. e1.

    Article 

    Google Scholar 

  • Endevelt R, et al. Intensive dietary intervention by a dietitian as a case manager among community dwelling older adults: the EDIT study. J Nutr Health Aging. 2011;15:624–30.

    Article 
    CAS 

    Google Scholar 

  • Cederholm T, Hellström K. Reversibility of protein-energy malnutrition in agroup of chronically-ill elderly outpatients. Clin Nutr. 1995;14(2):81–7.

    Article 
    CAS 

    Google Scholar 

  • Faxen-Irving G, et al. The effect of nutritional intervention in elderly subjects residing in group-living for the demented. Eur J Clin Nutr. 2002;56(3):221–7.

    Article 
    CAS 

    Google Scholar 

  • Zhang H, et al. The effect of oral nutritional supplements on the nutritional status of community elderly people with malnutrition or risk of malnutrition. Asia Pac J Clin Nutr. 2021;30(3):415–23.

    CAS 

    Google Scholar 

  • Arnaud-Battandier F, et al. Use of oral supplements in malnourished elderly patients living in the community: a pharmaco-economic study. Clin Nutr. 2004;23(5):1096–103.

    Article 
    CAS 

    Google Scholar 

  • Smith TR, et al., Ready-Made Oral Nutritional Supplements Improve Nutritional Outcomes and Reduce Health Care Use-A Randomised Trial in Older Malnourished People in Primary Care. Nutrients. 2020;12(2).

  • Assantachai P, et al. The benefits of a novel chicken-based oral nutritional supplement for older adults: A double-blind randomized controlled trial. Asia Pac J Clin Nutr. 2020;29(4):743–50.

    CAS 

    Google Scholar 

  • Xie H, et al. Nutrition education with or without oral nutrition supplements has contrasting effects on nutrition status in older adults: A randomized controlled study. Nutr Clin Pract. 2023;38(1):138–47.

    Article 
    CAS 

    Google Scholar 

  • Yeung SSY, JSW Lee, and T. Kwok. A Nutritionally Complete Oral Nutritional Supplement Powder Improved Nutritional Outcomes in Free-Living Adults at Risk of Malnutrition: A Randomized Controlled Trial. Int J Environ Res Public Health. 2022;19(18).

  • Edington J, et al. A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes. Clin Nutr. 2004;23(2):195–204.

    Article 
    CAS 

    Google Scholar 

  • van de Bool C, et al. A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD. J Cachexia Sarcopenia Muscle. 2017;8(5):748–58.

    Article 
    PubMed Central 

    Google Scholar 

  • Wouters-Wesseling W, et al. The effect of a liquid nutrition supplement on body composition and physical functioning in elderly people. Clin Nutr. 2003;22(4):371–7.

    Article 
    CAS 

    Google Scholar 

  • Payette H, et al. Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: A prospective randomized community trial. J Am Diet Assoc. 2002;102(8):1088–95.

    Article 

    Google Scholar 

  • Graydonald K, Payette H, Boutier V. RANDOMIZED CLINICAL-TRIAL OF NUTRITIONAL SUPPLEMENTATION SHOWS LITTLE EFFECT ON FUNCTIONAL STATUS AMONG FREE-LIVING FRAIL ELDERLY. J Nutr. 1995;125(12):2965–71.

    Article 
    CAS 

    Google Scholar 

  • Krondl M, et al. Subjectively healthy elderly consuming a liquid nutrition supplement maintained body mass index and improved same nutritional parameters and perceived well-being. J Am Diet Assoc. 1999;99(12):1542–8.

    Article 
    CAS 

    Google Scholar 

  • Kim CO, Lee KR. Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: A community-based randomized controlled study. Journals of Gerontology – Series A Biological Sciences and Medical Sciences. 2013;68(3):309–16.

    Article 
    CAS 

    Google Scholar 

  • Zhu L-Y, et al. Effects of exercise and nutrition supplementation in community-dwelling older Chinese people with sarcopenia: a randomized controlled trial. Age Ageing. 2019;48(2):220–8.

    Article 

    Google Scholar 

  • Multidisciplinary, three-dimensional and individualized comprehensive treatment for severe/critical COVID-19. Liver Res. 2020;4(3):109–117.

  • Smith TR, et al. Ready-made oral nutritional supplements improve nutritional outcomes and reduce health care use—a randomised trial in older malnourished people in primary care. Nutrients. 2020;12(2).

  • Giezenaar, C., et al., Ageing Is Associated with Decreases in Appetite and Energy Intake–A Meta-Analysis in Healthy Adults. Nutrients. 2016;8(1).

  • Johnson KO, et al. Differences in circulating appetite-related hormone concentrations between younger and older adults: a systematic review and meta-analysis. Aging Clin Exp Res. 2020;32(7):1233–44.

    Article 

    Google Scholar 

  • Perna S, et al. Are the therapeutic strategies in anorexia of ageing effective on nutritional status? A systematic review with meta-analysis. J Hum Nutr Diet. 2019;32(1):128–38.

    Article 
    CAS 

    Google Scholar 

  • Li M, et al. Effectiveness of oral nutritional supplements on older people with anorexia: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2021;13(3):835.

    Article 
    CAS 
    PubMed Central 

    Google Scholar 

  • Li M, et al. Effectiveness of Oral Nutritional Supplements on Older People with Anorexia: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13(3).

  • Cawood AL, Elia M, Stratton RJ. Systematic review and meta-analysis of the effects of high protein oral nutritional supplements. Ageing Res Rev. 2012;11(2):278–96.

    Article 
    CAS 

    Google Scholar 

  • Allen VJ, Methven L, Gosney MA. Use of nutritional complete supplements in older adults with dementia: systematic review and meta-analysis of clinical outcomes. Clin Nutr. 2013;32(6):950–7.

    Article 
    CAS 

    Google Scholar 

  • Reinders I, et al. Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials. Clin Nutr. 2019;38(4):1797–806.

    Article 

    Google Scholar 

  • Correa-Pérez A, et al. Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project. Ageing Res Rev. 2019;49:27–48.

    Article 

    Google Scholar 

  • White JV, et al. Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). J Acad Nutr Diet. 2012;112(5):730–8.

    Article 

    Google Scholar 

  • Wei J, et al. The association between low calf circumference and mortality: a systematic review and meta-analysis. European geriatric medicine. 2022;13(3):597–609.

    Article 

    Google Scholar 

  • Chou MY, et al. Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people. BMC Geriatr. 2019;19(1):186.

    Article 
    PubMed Central 

    Google Scholar 

  • van Wijngaarden JP, et al. Effects of Nutritional Interventions on Nutritional and Functional Outcomes in Geriatric Rehabilitation Patients: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2020;21(9):1207–1215.e9.

    Article 

    Google Scholar 

  • Veronese N, et al. Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis. Ageing Res Rev. 2019;51:48–54.

    Article 

    Google Scholar 

  • Cox NJ, et al. New horizons in appetite and the anorexia of ageing. Age Ageing. 2020;49(4):526–34.

    Article 

    Google Scholar 

  • Cox NJ, et al. Older individual’s perceptions of appetite, its loss, influencing factors and adaptions to poor appetite. A qualitative study Appetite. 2021;167: 105609.

    Google Scholar 

  • Landi F, et al. Anorexia of Aging: Risk Factors, Consequences, and Potential Treatments. Nutrients. 2016;8(2):69.

    Article 
    PubMed Central 

    Google Scholar 

  • Soenen S, Chapman IM. Body weight, anorexia, and undernutrition in older people. J Am Med Dir Assoc. 2013;14(9):642–8.

    Article 

    Google Scholar 

  • Van Wymelbeke V, et al. An innovative brioche enriched in protein and energy improves the nutritional status of malnourished nursing home residents compared to oral nutritional supplement and usual breakfast: FARINE+ project. Clin Nutr ESPEN. 2016;15:93–100.

    Article 

    Google Scholar 

  • Chapman IM. Weight loss in older persons. Med Clin North Am. 2011;95(3):579–93. xi.

    Article 

    Google Scholar 

  • Chang M, et al. A poor appetite or ability to eat and its association with physical function amongst community-dwelling older adults: age, gene/environment susceptibility-Reykjavik study. Eur J Ageing. 2021;18:405–15.

    Article 

    Google Scholar 

  • Elia M, et al. A systematic review of the cost and cost effectiveness of using standard oral nutritional supplements in the hospital setting. Clin Nutr. 2016;35(2):370–80.

    Article 
    CAS 

    Google Scholar 

  • Ryan M, et al. Oral supplements differing in fat and carbohydrate content: effect on the appetite and food intake of undernourished elderly patients. Clin Nutr. 2004;23(4):683–9.

    Article 
    CAS 

    Google Scholar 

  • Parsons EL, et al. Oral nutritional supplements in a randomised trial are more effective than dietary advice at improving quality of life in malnourished care home residents. Clin Nutr. 2017;36(1):134–42.

    Article 

    Google Scholar 

  • Hubbard GP, et al. A systematic review of compliance to oral nutritional supplements. Clin Nutr. 2012;31(3):293–312.

    Article 

    Google Scholar 


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