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Neuronal hypoglycolysis sustains body health

Neurons have a high energy cost mainly sustained by glucose, but paradoxically present a weak glycolysis. This fact is now shown to account for healthy bioenergetics, reduced mitochondrial redox stress and whole-body fitness. Mice with high glycolytic rates in neurons present impaired autophagy, cognitive defects and metabolic-like syndrome.

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Fig. 1: Weak glycolysis in neurons is required to sustain higher-order organismal functions.

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Authors and Affiliations

  1. Instituto Universitario de Biología Molecular-UAM (IUBM-UAM), Departamento de Biología Molecular, Universidad Autónoma de Madrid (UAM), Madrid, Spain

    Beatriz Pardo

  2. Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid- Consejo Superior de Investigaciones Científicas (UAM-CSIC), Madrid, Spain

    Beatriz Pardo

  3. Instituto de Investigaciones Sanitarias Fundación Jiménez Díaz (IIS-FJD), UAM, Madrid, Spain

    Beatriz Pardo

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Pardo, B. Neuronal hypoglycolysis sustains body health.
Nat Metab (2024). https://doi.org/10.1038/s42255-024-01055-2

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  • Published: 24 May 2024

  • DOI: https://doi.org/10.1038/s42255-024-01055-2

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